Effect of prenatal administration of haloperidol,risperidone, quetiapine and olanzapine on spatial learning and retention in adult rats |
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Authors: | Rosengarten Helen Quartermain David |
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Affiliation: | Department of Psychiatry, Millhauser Laboratories, New York University School of Medicine, 550 First Avenue, New York 10001, USA. helenrosengarten@nyu.med.edu |
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Abstract: | The typical antipsychotic haloperidol and atypical antipsychotics olanzapine, quetiapine and risperidone were administered to pregnant Sprague-Dawley dams in the drinking water from Days 8 to 18 of gestation. When the offspring reached adulthood (2 months), spatial learning and short-term retention were examined using the radial arm maze. Results showed that prenatal administration of haloperidol, risperidone and quetiapine impaired learning but only haloperidol and risperidone disrupted short-term retention. |
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