脑膜免疫在中枢神经系统疾病中的研究进展

脑膜作为包绕中枢神经系统（central nervous system，CNS）的4层膜状结构，含有大量免疫细胞，是中枢神经系统的重要屏障和通道，但是其具体的免疫机制尚不明确。近年来，脑膜淋巴管的发现揭示了脑膜在清除大脑代谢物、参与免疫监视与免疫反应等方面的作用。本文主要就脑膜免疫的相关研究进展以及脑膜免疫对相关疾病的影响进行综述，同时展望脑膜免疫未来的研究方向。

Research progress on of the meningeal immunity in central nervous system diseases

The meninges，a four-layer membrane-like enclosure around the central nervous system（CNS），house a significant population of immune cells and is an important barrier and pathway for entering the CNS；however，the specific immune processes remain elusive. Recent identification of meningeal lymphatic vessels has shed light on the involvement of meninges in metabolite clearance，immune surveillance and response. Here，we provide a comprehensive review of advancements in meningeal immunity research and its implications for associated disorders. Additionally，potential avenues for future investigations in the realm of meningeal immunity are suggested.