| 丁胱亚磺酰亚胺对Acc—2细胞的放射增敏效应研究 |
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| 引用本文： | 万光勇,林国础.丁胱亚磺酰亚胺对Acc—2细胞的放射增敏效应研究[J].上海口腔医学,1999,8(3):134-137. |
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| 作者姓名： | 万光勇 林国础 |
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| 作者单位： | [1]山东省泰安市中心医院口腔科 [2]上海第二医科大学口腔医学院口腔外科教研室 |
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| 摘 要： | 目的 研究新型放射增敏剂丁胱亚磺酰亚胺（ｂｕｔｈｉｏｎｅ ｓｕｌｆｏｘｉｍ ｉｎ， Ｂ Ｓ Ｏ）对 Ａｃｃ２ 细胞的放射增敏效应。方法 采用克隆形成法，首先观察了 Ｂ Ｓ Ｏ 在乏氧状态和有氧状态下对 Ａｃｃ２ 细胞的药物毒性，然后研究了 Ｂ Ｓ Ｏ 在乏氧和有氧状态下对 Ａｃｃ２ 细胞的放射增敏效应。结果 Ｂ Ｓ Ｏ 在乏氧状态和有氧状态时，其半数抑制剂量分别为８０μｍ ｏｌ／ Ｌ、１２０μｍ ｏｌ／ Ｌ。当 Ｂ Ｓ Ｏ 在 Ｉ Ｄ２０、 Ｉ Ｄ１０ 的药物剂量时，在乏氧状态下，其 Ｓ Ｅ Ｒ 值分别为１５２１ 和１２６３，在有氧状态下其 Ｓ Ｅ Ｒ 值分别为１２９６ 和１１５３。结论 Ｂ Ｓ Ｏ 对 Ａｃｃ２ 细胞有放射增敏作用， Ｂ Ｓ Ｏ 在乏氧状态下的增敏效应比有氧状态下的放射增敏效应强。
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| 关 键 词： | 丁胱亚磺酰亚胺 Acc-2细胞 放射增敏 |
Studies of radiosensitizative effect of BSO on Acc 2 cells |
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| G Y Wan,G C Lin,Z H Wang,W T Chen.Studies of radiosensitizative effect of BSO on Acc 2 cells[J].Shanghai Journal of Stomatology,1999,8(3):134-137. |
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| Authors: | G Y Wan G C Lin Z H Wang W T Chen |
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| Institution: | Department of Oral & Maxillofacial Surgery, School of Stomatology, Shanghai Second Medical University. Shanghai 200011 China. |
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| Abstract: | OBJECTIVE:To study the radiosensitizative effect of buthione sulfoximin (BSO) on Acc-2 cells.METHODS:First,the pharmotoxicity of BSO to Acc-2 cells under hypoxic or aerobic conditions was measured.Second,the radiosensitizative effect of BSO on Acc-2 cells under hypoxic or aerobic conditions was studied.Plating efficiency assay was used in this experiment.RESUTS:The 50% inhibition dose (ID50) of BSO to Acc-2 cells under hypoxic or aerobic condition was 80 micromol/L,120micromol/L,respectively.When the dose of BSO was ID20 and ID10 under hypoxic or aerobic condition the SER was 1.521,1.263 and 1.296,1.153,respectively.CONCLUSION:BSO had radiosensitizative effect on Acc-2 cells both under hypoxic or aerobic condition.The radiosensitizative effect of BSO on Acc-2 cells under hypoxic condition was stronger than that under aerobic condition. |
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| Keywords: | buthione sulfoximine (BSO) Acc 2 cells radiosensitizative effect |
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