1H-MRS在轻度认知障碍中的研究进展

轻度认知障碍（Mild cognitive impairment,MCI）是介于正常老化和痴呆之间的一种过渡阶段的认知功能障碍,是一种存在主诉记忆障碍主诉和客观认知损伤的临床综合征.MCI患者是阿尔茨海默氏病（AD）或其他痴呆症患者的高危人群.磁共振功能成像技术不仅能够测量解剖结构,反映生化和微观结构特点,而且能提供功能方面的信息,被认为是早期诊断和评估MCI的有效方法,尤其是质子磁共振磁共振波谱（1H-MRS）作为目前唯一无创性活体研究组织代谢、生化变化和化合物定量分析的磁共振方法,有助于帮助识别和寻找老年人典型MCI的病因,已成为近年来研究MCI的热点.

Progress of 1H-MRS in mild cognitive impairment

Mild cognitive impairment （MCI） is the cognitive dysfunction of a transitional stage between nor- mal aging and dementia, and also is a clinical syndrome for a chief complaint of memory impairment complaints and objective cognitive impairment. Many individuals with MCI are at the prodromal stage of Alzheimer＇s disease （AD） or other dementia. Functional magnetic resonance imaging is an emerging technology, not only to be capable of display- ing human physiological and pathophysiological processes, but also to provide dynamic and functional information, and to be recognized as an effective method of the early diagnosis and assessment of MCI. Proton magnetic resonance spectroscopy （＇H-MRS） metabolite markers may help identify and track etiologies that typically underlie MCI in the el- derly. The role of proton MRS has become a research hotspot in recent years.