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| 糖基化终末产物对大鼠骨髓来源内皮祖细胞增殖、凋亡和管腔形成的影响 | |
| 引用本文： | 成永霞,刘贵波,孙成,李志强,郭素芬,颜彬,于建渤,杨向红.糖基化终末产物对大鼠骨髓来源内皮祖细胞增殖、凋亡和管腔形成的影响[J].微循环学杂志,2012,22(1):30-32,F0004,I0001. |
| 作者姓名： | 成永霞 刘贵波 孙成 李志强 郭素芬 颜彬 于建渤 杨向红 |
| 作者单位： | 1. 黑龙江省牡丹江医学院病理教研室,牡丹江,157011 2. 黑龙江省牡丹江医学院解剖教研室 3. 中国医科大学附属盛京医院病理科 |
| 基金项目： | 黑龙江省青年科学基金项目（QC2010040）; 黑龙江省自然科学基金项目（D2008-83）; 黑龙江省卫生厅项目（2006-39） |
| 摘 要： | 目的:观察糖基化终末产物(AGEs)对骨髓来源内皮祖细胞(EPCs)动员及生物功能的影响。方法:采用不同浓度牛血清白蛋白糖基化终末产物(BSA-AGEs)(50～200mg/L)分别作用EPCs(0～24h),检测EPCs的增殖、凋亡及管腔形成能力的变化。结果:随着AGEs浓度增加及作用时间的延长,EPCs的凋亡率升高,而增殖及管腔形成能力降低(P<0.05)。结论:AGEs对EPCs的存活和增殖具有损害作用,而且还对EPCs功能有破坏作用。 |
| 关 键 词： | 糖基化终末产物 骨髓来源内皮祖细胞 增殖 凋亡 管腔形成 |
The Influnce of AGEs on Prolifiatation,Apopotosis and Tube Formation of Endothelial Progenitor Cells in Rat Bone Marrow |
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| Institution: | Cheng Yongxia,Liu Guibo,Sun Cheng,et al Department of Pathology,Mudanjiang Medical College,Mudanjiang 157011 |
| Abstract: | Objective:To observe the effect of the advanced glycation end products(AGEs) on prolifiatation,apopotosis and tube formation of endothelial progenitor cells(EPCs).Method:The EPCs were cultured in vitro.After AGEs of the different dose(50～200mg/L)and different times(0～24h) played the role on the cells,the prolifiatation,apopotosis and tube formation of EPCs of all groups were detected.Results:Prolifiatation and tube formation of EPCs decreased with the AGEs dose increasing and treatment time prolong,while EPCs opopotosis rate increased.Statistical analysis of the results have significantly differences.Conclusion:These results demonstrated that AGEs may effect on the vascular recover at diabetets through increase apopotosis of EPCs and decrease its proliferation and tube formation. |
| Keywords: | Advanced glycaton end products Endothelial progentor cell Proliferation Apopotosis Tube formation |
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