| 甲基硝基亚硝基胍诱发小鼠膀胱肿瘤早期病变的动态观察 |
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| 引用本文： | 武文森,尹克铮.甲基硝基亚硝基胍诱发小鼠膀胱肿瘤早期病变的动态观察[J].东南大学学报(医学版),1990(4). |
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| 作者姓名： | 武文森 尹克铮 |
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| 作者单位： | 南京铁道医学院病理教研室，南京铁道医学院病理教研室 |
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| 摘 要： | 本项研究采取膀胱灌注 MNNG 诱发小鼠膀胱肿瘤,对 MNNG 引起膀胱上皮早期病变进行了动态观察。肿瘤的发生,发展经历了从单纯增生,乳头状,结节状增生,良性乳头状瘤,非浸润癌浸润癌这样一个典型的病理过程。诱发的膀胱肿瘤均为移行细胞肿瘤。
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| 关 键 词： | 甲基硝基亚硝基胍 膀胱肿瘤 致癌物 小鼠实验 |
EARLY PATHOLOGICAL CHANGES IN BLADDER TUMOR OF MICE INDUCED BY N-METHYL-N-NITRO-N-NITROSOGUANIDINE |
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| Wu Wensen Yin Kezheng.EARLY PATHOLOGICAL CHANGES IN BLADDER TUMOR OF MICE INDUCED BY N-METHYL-N-NITRO-N-NITROSOGUANIDINE[J].Journal of Southeast Univ: Medical Sci Ed,1990(4). |
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| Authors: | Wu Wensen Yin Kezheng |
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| Abstract: | Experimental bladder tumors were induced in female mice by intravescical infus- ion of N-methyl-N-nitro-N-nitrosoguanidine.Early changes in the bladder epithelium of mice were studied.Our observations show that the lesions have a typical course of hyperplasia,noninvasive papilloma and invasive carcinoma and the tumors consist of transitical cells. |
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| Keywords: | N-methyl-N-nitro-N-nitrosoguanidine bladder carcinoma carcinogens mice laboratory |
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