齐拉西酮对慢性精神分裂症患者生活质量影响的临床研究

目的探讨齐拉西酮对慢性精神分裂症患者生活质量的影响。方法将使用传统抗精神病药进行维持治疗的慢性精神分裂症门诊患者30例换用新型抗精神病药齐拉西酮治疗6个月。采用阳性与阴性症状量表(PANSS)、不良反应量表(TESS)、精神分裂症患者生活质量量表(SQLs)及社会功能缺陷筛选表(SDSS)分别评定换用齐拉西酮治疗前后患者的疗效、不良反应及生活质量情况。结果换用齐拉西酮治疗6月后,PANSS中阴性症状、TESS、SQLs、SDSS评分均显著下降。结论齐拉西酮能显著改善慢性精神分裂症患者的生活质量。

A Clinical Study of the Influence of Ziprasidone on the Quality of Life in Patients with Chronic Schizophrenia

Objective To explore the treatment effects of ziprasidone on the quality of life in chronic schizophrenia patients. Methods 30 cases of chronic schizophrenic outpatient in maintenance treatment period were recruited in present study. Ziprasidone were used to substitute the traditional antipsychotics for six months, and the positive and negative symptom scale （PANSS）,the treatment emergent symptom scale（TESS）, the schizophrenia quality of life scale （SQLS）and the social disability screening schedule（SDSS）were used to evaluate efficacy, side effects and quality of life. Results After the treatment for six months, all the scores of PANSS-negative symptom scale, TESS, SQLS and SDSS were significant decreased. Conclusion Ziprasidone can improve the quality of life of chronic schizophrenic patients.