Multiple Choice Questions |
| |
| Abstract: | |
Serotonin and anaesthesia
| - 1. Serotonin (5-HT):
- Is produced from tryptophan.
- Is foundin platelets and mast cells.
- Has only 3 receptor subtypes.
- Acts at both the chemoreceptor trigger zone and the vomitingcentre.
- Is devoid of effect on the heart.
- 2. SelectiveSerotonin-Reuptake Inhibitors (SSRIs):
- The mechanismof serotoninsyndrome is overstimulation of central5-HT receptors.
- Mustalways be stopped in the perioperative period.
- Aresafe incombination with high doses of tricyclic antidepressants.
- Hyperreflexiaand clonus are manifestations of CNS toxicity.
- Neurolepticmalignant syndrome is a consequence of overdose.
- 3. 5-HTreceptor agonists and antagonists:
- 5-HT3 antagonistsmust alwaysbe given as sole agents for PONV.
- Triptans are5-HT1 receptoragonists.
- Triptans are indicated for the prodromalphase ofmigraine.
- 5-HT4 agonism has anti-anginal utility.
- Ketanserinis a 5-HT2 receptor antagonist.
- 4. In pre-eclampsia:
-
| |
| Keywords: | |
| 本文献已被 Oxford 等数据库收录！ |
|
