The development of peripartum depressive symptoms is associated with gene polymorphisms of MAOA, 5-HTT and COMT |
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Authors: | Bennard Doornbos D.A. Janneke Dijck-Brouwer Ido P. Kema Marit A.C. Tanke Saskia A. van Goor Frits A.J. Muskiet Jakob Korf |
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Affiliation: | 1. Graduate School of Behavioral and Cognitive Neuroscience, University Center for Psychiatry, University Medical Center Groningen, The Netherlands;2. Laboratory Center, University Medical Center Groningen, The Netherlands;3. University Medical Center Groningen EA 61, P.O. Box 30.001, 9700 RB Groningen, The Netherlands;4. University Center for Psychiatry CC64, University Medical Center Groningen, Hanzeplein 1, P.O. Box 30.001, 9700 RB Groningen, The Netherlands;5. University Medical Center Groningen EA 22, P.O. Box 30.001, 9700 RB Groningen, The Netherlands |
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Abstract: | BackgroundPolymorphisms of monoamine-related genes have been associated with depression following life events. The peripartum is a physiologically and psychologically challenging period, characterized by fluctuations in depressive symptoms, therefore facilitating prospective investigations in this gene × environment (G × E) interaction.MethodsEighty nine pregnant women filled in two Edinburgh Postpartum Depression Scale (EPDS) questionnaires during pregnancy and two in the postpartum period. MAOA, COMT and 5-HTT polymorphisms were analyzed.ResultsWe found a significant interaction between the development of depressive symptoms in the course of pregnancy and polymorphisms in 5-HTT (p = 0.019); MAOA (p = 0.044) and COMT (p = 0.026), and MAOA × COMT (p < 0.001). Particularly, women carrying the combination of low activity variants of MAOA and COMT showed increased EPDS scores at week 36 of pregnancy and 6 weeks postpartum, but not during early pregnancy or 12 weeks postpartum.ConclusionWe found that MAOA in combination with COMT appears to regulate not only the stress response in laboratory experiments, but also seems to influence the stress-evoked onset of mood during normal, mild, stressful events, such as experienced in the peripartum period. These findings support the G × E concept for depression, but they underline the complexity of this concept, as the cumulating effects of these polymorphic genes (i.e. MAOA + COMT) might be needed and the effects of these polymorphic genes becomes apparent in special environmental or physiological conditions (i.e. the peripartum period). We therefore suggest that G × E interactions become especially noticeable from longitudinal study designs in specific physiological or social challenging periods. |
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Keywords: | 5-HTTLPR COMT Depressive symptoms Gene environment interaction MAOA Peripartum |
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