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Mutational specificity of 2-nitro-3,4-dimethylimidazo[4,5-f]quinoline in the lacI gene of Escherichia coli |
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| Authors: | Kosakarn, P. Halliday, J.A. Glickman, B.W. Josephy, P.D. |
| Affiliation: | Guelph-Waterloo Center for Graduate Work in Chemistry, Department of Chemistry and Biochemistry, University of Guelph Guelph, Ontario NIG 2WI 1Department of Biology, York University Downsview, Ontario M3J 1P3 2Center for Environmental Health, University of Victoria Sidney, B.C. V8L 3S1, Canada |
| Abstract: | 2-Nitro-3,4-dimethylimidazo[4,5-f]quinoline (NO2-MeIQ) is thenitro derivative of 2-amino-3,4-dimethylimi-dazo[4,5-f]quinoline(MeIQ), one of the food pyrolysis product mutagens and carcinogens.The mutational specificity of NO2-MeIQ was determined usingthe lacI system in an Escherichia coli strain, EE125, harbouringthe plasmid pKM101. NO2-MeIQ acts as a direct-acting mutagentowards this strain, and induces a broad range of mutationalalterations. At higher doses; G:C |
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