Catechol-O-methyltransferase (COMT) val158met polymorphism as a risk factor for PTSD after urban violence |
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Authors: | Valente Nina Leão Marques Vallada Homero Cordeiro Quirino Bressan Rodrigo Affonseca Andreoli Sergio Baxter Mari Jair Jesus Mello Marcelo Feijó |
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Institution: | (1) Departamento de Psiquiatria, Universidade Federal de S?o Paulo, Rua Botucatu 431 - Villa Clementino, CEP 04023-061 S?o Paulo, SP, Brazil;(2) King’s College London, Health Service and Population Research Department, Institute of Psychiatry, London, United Kingdom;(3) Departamento de Psiquiatria da Faculdade de Medicina da Universidade de S?o Paulo, S?o Paulo, Brazil |
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Abstract: | PTSD is a psychiatric disorder that requires a traumatic event as diagnostic criteria. Brazil has high rates of violence,
and it is expected that urban victims of violence would be at risk to the development of PTSD. Studies have associated the
COMT val158met polymorphism with diminished stress resilience, reduced ability to extinguish conditioned fear, and the development
of PTSD after multiple traumatic experiences. The aim of this study was to identify, in a case–control study, whether the
val158met polymorphism (rs4860) is associated with the development of PTSD in a group of victims of urban violence. To our
knowledge, this is the first study that examines the association between PTSD and urban violence. The polymorphism of COMT
in PTSD patients (n = 65) as well as in victims of violence without PTSD (n = 34) and in a community control group (n = 335) were genotyped. We found a significant relationship between the met allele (p < 0.02) and PTSD among cases (PTSD+)and victims of violence without PTSD (PTSD−; OR 2.57) and between cases and community
control group (p < 0.003) Further analysis with larger samples and another ethnic group should be necessary to confirm our findings. |
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