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Aberrant splicing in the presenilin-1 intron 4 mutation causes presenile Alzheimer's disease by increased Abeta42 secretion. |
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| Authors: | C De Jonghe M Cruts E A Rogaeva C Tysoe A Singleton H Vanderstichele W Meschino B Dermaut I Vanderhoeven H Backhovens E Vanmechelen C M Morris J Hardy D C Rubinsztein P H St George-Hyslop C Van Broeckhoven |
| Affiliation: | Department of Molecular Genetics, Flanders Interuniversity Institute for Biotechnology (VIB), Laboratory of Molecular Genetics, Born-Bunge Foundation (BBS), University of Antwerp (UIA), Antwerpen, Belgium. |
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