| 联立方程分光光度法测定复方苯甲酸醇溶液中两组分含量 |
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| 引用本文： | 张革,张丽梅,吴国海. 联立方程分光光度法测定复方苯甲酸醇溶液中两组分含量[J]. 中国药业, 2009, 18(17): 19-20 |
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| 作者姓名： | 张革 张丽梅 吴国海 |
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| 作者单位： | 1. 中国人民解放军海军总医院,北京,100037
2. 中国人民解放军北京军区北戴河疗养院,河北,秦皇岛,066001 |
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| 摘 要： | 目的建立复方苯甲酸醇溶液中苯甲酸和水杨酸的含量测定方法。方法采用联立方程分光光度法，直接测定复方苯甲酸醇溶液中苯甲酸和水杨酸的含量。结果以229nm和236nm分别为苯甲酸和水杨酸的测定波长，以0．1mol／L的盐酸为空白，苯甲酸质量浓度在2．535～17．745μg／mL，水杨酸质量浓度在1．265～8．855μg／mL范围内与吸收度线性关系良好，平均回收率分别为99．08％和98．70％，RSD分别为0．93％和0．88％（n=5）。结论联立方程分光光度法简便、快速、可靠，适合于复方苯甲酸醇溶液的快速检测。
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| 关 键 词： | 联立方程分光光度法 苯甲酸 水杨酸 含量测定 |
Content Determination of Two Components in Compound Benzoic Acid Alcohol Solution by Simultaneous Equations |
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| Zhang Ge,Zhang Limei,Wu Guohai. Content Determination of Two Components in Compound Benzoic Acid Alcohol Solution by Simultaneous Equations[J]. China Pharmaceuticals, 2009, 18(17): 19-20 |
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| Authors: | Zhang Ge Zhang Limei Wu Guohai |
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| Affiliation: | 1. Navy General Hospital of PLA, Beijing, China 100037; 2. Beidaihe Sanatorium of Beijing Military Region, Qinhuangdao, Hebei, China 066001) |
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| Abstract: | Objective To establish a method for the determination of benzoic acid and salicylic acid in Compound Benzoic Alcohol Solution. Methods Simultaneous equations of spectrophotometer were applied to direct determination of two components benzoic acid and salicylic acid. Results The detected wavelengths of benzoic acid and salicylic acid were 229 nm and 236 nm respectively. 0. 1 mol/L hydrochloric acid was used as blank reference. Benzoic acid and salicylic acid showed the good linear relationship in the range of 2. 535 - 17. 745 μg/mL and 1. 265 - 8. 855 μg/mL respectively. The average recovery rate was 99.08%, RSD = 0. 93% for benzoic acid and 98.70%, RSD = 0. 88% for salicylic acid respectively. Conclusion The present method is simple, convenient and reliable, which is suitable for rapid determination of Compound Benzoic Acid Alcohol Solution. |
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| Keywords: | simultaneous equations of spectrophotometry benzoic acid salicylic acid content determination |
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