外周血CD34~+细胞与急性脑梗死及脑血管病危险因素的相关性

目的:探讨急性脑梗死是否会动员CD34+细胞到外周血及其与脑血管病危险因素的相关性。方法:筛选急性脑梗死32例(A组),脑血管病危险因素32例(B组),健康对照组20例(C组)。流式细胞仪测定外周血CD34+含量。结果:①A、B、C 3组CD34+含量分别为(0.036±0.023)%,(0.073±0.021)%和(0.094±0.022)%,有显著性差异(P<0.001)。②CD34+含量与高血压、糖尿病呈负相关,与HDL-C/LDL-C呈正相关(P<0.05)。吸烟,TC,HDL,LDL与CD34+无相关性(P>0.05)。③高血压、糖尿病、HDL/LDL是CD34+含量的独立影响因素(P<0.05)。④CD34+含量越低,CSS评分越高。结论:①急性脑梗死动员CD34+细胞到外周血效率差。②脑血管病危险因素中高血压、糖尿病患者外周血中CD34+含量降低,HDL-C/LDL-C增高能增加外周血中CD34+含量,可能通过影响其危险因素参与了急性脑梗死的发生发展。

Relationship of Circulating CD34+ Progenitor Cells with Acute Cerebral Infarction and Cerebrovascular Disease''s Risk Factors

Objective: To explore whether or not acute cerebral vascular infarction can mobilize CD34+ cells to peripheral blood,and to study the association between the count of circulating CD34+ cells and various risk factors of cerebrovascular disease.Methods: Patients with acute cerebral infarction(n=32)(group A) and patients with cerebrovascular risk factors and without cerebral infaction(n=32)(group B) were screened out.Twenty volunteers(group C) were chosen as healthy controls.The number of CD34+ cells in peripheral blood was analyzed by flow cytometer.Results: The percentage of the circulating CD34+ cells was(0.036±0.023)%,(0.073 ±0.021)% and(0.095±0.022)% in group A,B and C,respectively,with significant difference among them(P<0.05).② Hypertension and diabetes mellitus were inversely correlated with the percentage of circulating CD34+/PMNC,while HDL-C/LDL-C level was negatively correlated with it(P<0.05).③ Hypertensive disease,diabetes mellitus and HDL /LDL were the independent influence factors of percentage of CD34+/PMNC(all P<0.05).④ The lower of CD34+,the higher score of CSS.Conclusion: The mobilization of the circulating CD34+ progenitor cells into peripheral blood is weak in blood acute cerebral infraction.Hypertensive disease and diabetes mellitus could reduce the circulating CD34+ progenitor cells and higher level of HDL-C/LDL-C could increase it.The circulating CD34+ progenitor cells possibly participate in the course of acute cerebral infarction with relation to risk factors.