Formation of new lymphatic vessels in glioma: An immunohistochemical analysis |
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| Authors: | Fan-Wei Meng Fu-Sheng Liu Wen-Hui Liu Li Li Lin-Lin Jie |
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| Institution: | 1. Department of Anatomy and Physiology, Shandong College of Traditional Chinese Medicine, Yantai, China;2. Department of Neurosurgery, Beijing Tiantan Hospital Affiliated to Capital Medical University, Beijing Neurosurgical Institute, Beijing, China |
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| Abstract: | We investigated the distribution and formation of new lymphatic vessels in gliomas. Specimens from seven glioma cases were analyzed by immunohistochemical staining for CD34, lymphatic endothelial hyaluronic acid receptor 1 (LYVE-1), prospero-related homeobox 1 (Prox1), nestin, and hypoxia-inducible factor 1α (HIF-1α). Three types of vessels were observed in glioma specimens: LYVE-1+ lymphatic vessels, CD34+ blood vessels, and LYVE-1+/CD34+ blood vessels. Prox1+/LYVE-1+ cells were distributed in some lymphatic vessels as well as among vascular endothelial cells and glioma cells. Nestin+ cells were scattered throughout the gliomas, and some lymphatic cells also expressed nestin. HIF-1α+ Prox1+ cells were widely distributed within the glioma specimens. The present immunohistochemical analysis revealed upregulation of Prox1 and HIF-1α in some glioma tissues as well as the differentiation of nestin+ tumor stem cells into LYVE-1+ lymphatic vessels. |
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| Keywords: | glioma hypoxia-inducible factor 1α lymphatic endothelial hyaluronic acid receptor 1 lymphatic vessels Prospero-Related Homeobox 1 |
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