乳腺自动全容积成像联合超声造影对乳腺导管内病变诊断价值的研究

目的：分析乳腺自动全容积成像联合超声造影对乳腺导管内病变诊断价值。方法：前瞻性研究选取2021年8月-2023年3月于本院接受治疗的110例乳腺疾病患者为本次研究对象,计划110例患者作研究对象（考虑有10%的脱落率,选取样本由100例提至110例）。由于部分患者的双侧乳房存在病变的状况,此次研究按病理学检验结果、研究目的将其分成导管内病变组（60例）与非导管内病变组（50例）,同时对于患者双侧同时伴有病变,只要一侧诊断为导管内病变即可作为导管内病变组。结果：经分析显示,超声造影对患者乳腺导管内病变的检测结果与年龄、边缘、病灶增强特征、回声变化无关（P>0.05）;而与病灶达峰强度、病灶形态、直径、周边放射状增强、达峰增强使扩大径线变化有关（P<0.05）。乳腺自动全容积成像检测乳腺导管内病变患者的结果与年龄、肿块形态、回声、边缘变化无关（P>0.05）;而与微钙化、肿块位置、伴有结构变化有关（P<0.05）。在乳腺导管内阴、阳性病变诊断中二者联合检测明显高于超声造影、乳腺自动全容积成像单一检测（P＜0.05）。与超声造影、乳腺自动全容积成像单项诊断相比,两者联合诊断乳腺导管内阳性病变的敏感度、特异度、准确性均较优（P＜0.05）结论：乳腺自动全容积成像、超声造影联合诊断乳腺导管内病变具有较高的敏感度、特异度及准确度,可及时明确病变的类型及发展情况,为临床制定有效治疗措施提供了参考。

Study on the value of breast automatic total volume imaging combinedwith contrast-enhanced ultrasound in the diagnosis of breast intraductal

Objective: To analyze the diagnostic value of automatic full volume breast imaging combined with contrast-enhanced ultrasound in intraductal breast lesions. Methods: In the Prospective cohort study, 110 patients with breast diseases who were treated in our hospital from August 2021 to March 2023 were selected as the subjects of this study, and 110 patients were planned to be the subjects of this study (considering a 10% dropout rate, the selected samples were raised from 100 to 110 cases). Due to the presence of lesions on both breasts of some patients, this study divided them into an intraductal lesion group (60 cases) and a non-intraductal lesion group (50 cases) based on pathological examination results and research purposes. For patients with bilateral concurrent lesions, as long as one side is diagnosed as an intraductal lesion, it can be classified as an intraductal lesion group. Results: The analysis showed that the detection results of breast intraductal lesions had nothing to do with age, edge, enhancement features and echo changes (P>0.05). However, it was related to lesion peak intensity, lesion shape, diameter, peripheral radial enhancement and the change of expanded diameter with lesion peak enhancement (P<0.05). The results of breast automatic full-volume imaging were not correlated with age, mass shape, echo, and marginal changes (P>0.05). It was associated with microcalcification, tumor location and structural changes (P<0.05). In the diagnosis of breast duct vulva and positive lesions, the combined detection was significantly higher than that of CEUS and automatic full volume imaging (P<0.05). Compared with the single diagnosis of contrast-enhanced ultrasound and automatic breast full volume imaging, the sensitivity, specificity and accuracy of the combined diagnosis of positive breast duct lesions were better (P<0.05). Conclusion: The combination of automatic full volume imaging and contrast-enhanced ultrasound in the diagnosis of intraductal breast lesions has high sensitivity, specificity and accuracy, which can identify the type and development of lesions in time, and provide a reference for clinical formulation of effective treatment measures.