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Periodontal disease as a possible cause for Alzheimer's disease |
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| Authors: | Angela R. Kamer Ronald G. Craig Richard Niederman Juan Fortea Mony J. de Leon |
| Affiliation: | 1. Department of Periodontology and Implant Dentistry, New York University, College of Dentistry, New York, New York, USA;2. Department of Periodontology and Implant Dentistry, New York University, College of Dentistry, New York, New York, USA Department of Basic Sciences and Craniofacial Biology, New York University, College of Dentistry, New York, New York, USA;3. Department of Epidemiology and Health Promotion, New York University, College of Dentistry, New York, New York, USA;4. Alzheimer Down Unit, Department of Neurology, Hospital de la Santa Creu i Sant Pau- Biomedical Research Institute Sant Pau- Universitat Autònoma de Barcelona and Barcelona Down Medical Center, Fundació Catalana Síndrome de Down, Barcelona, Spain Alzheimer's Disease and Other Cognitive Disorders Unit, Neurology Service, Hospital Clínic, Barcelona, Spain;5. Department of Radiology, Brain Health Imaging Institute, Weill Cornell Medicine, New York, New York, USA |
| Abstract: | Approximately 47 million people worldwide have been diagnosed with dementia, 60%-80% of whom have dementia of the Alzheimer’s disease type. Unfortunately, there is no cure in sight. Defining modifiable risk factors for Alzheimer’s disease may have a significant impact on its prevalence. An increasing body of evidence suggests that chronic inflammation and microbial dysbiosis are risk factors for Alzheimer’s disease. Periodontal disease is a chronic inflammatory disease that develops in response to response to microbial dysbiosis. Many studies have shown an association between periodontal disease and Alzheimer’s disease. The intent of this paper was to review the existing literature and determine, using the Bradford Hill criteria, whether periodontal disease is causally related to Alzheimer’s disease. |
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