A case of neonatal pemphigus vulgaris with co-existing BP180 autoantibodies |
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Authors: | Justine Fenner MD Michelle S. Min MD MS Stephanie Liu DO MBA Nanette Silverberg MD |
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Affiliation: | 1. Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York, New York;2. Department of Dermatopathology, Icahn School of Medicine at Mount Sinai, New York, New York;3. Departments of Dermatology and Pediatrics, Icahn School of Medicine at Mount Sinai, New York, New York |
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Abstract: | A male neonate was born with blisters on the trunk to a 37-year-old primigravid woman with a past medical history of recurrent, painful, topical steroid-responsive oral blisters. The diagnosis of neonatal pemphigus was made after the neonate and mother were found to have elevated desmoglein 3 (Dsg3) antibodies in conjunction with histopathologic features of pemphigus vulgaris. Interestingly, both neonate and mother also had elevated levels of BP180 antibodies, classically seen in bullous pemphigoid. This case is unique in that it portrays neonatal pemphigus, an already rare condition, complicated by the presence of BP180 antibodies. |
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Keywords: | bullous disease-immunologic neonatal |
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