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Formation and growth of gap junctions in mouse myocardium during ontogenesis: quantitative data and their implications on the development of intercellular communication. |
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| Authors: | D Gros J P Mocquard C E Challice J Schrevel |
| Affiliation: | 1. Laboratoire de Zoologie et de Biologie cellulaire, UER Sciences Fondamentales et Appliquées, 40, Avenue du Recteur Pineau, Poitiers Cedex 86022, France;2. Service Général de Microscopie Electronique Appliquée à la Biologie, UER Sciences Fondamentales et Appliquées, 40, Avenue du Recteur Pineau, Poitiers Cedex 86022, France;3. Laboratoire de Physiologie et Génétique des Crustacés, UER Sciences Fondamentales et Appliquées, 40, Avenue du Recteur Pineau, Poitiers Cedex 86022, France;4. Physics Department, University of Calgary, Calgary, Alberta T2N 1N4, Canada |
| Abstract: | The results of a study on the formation and growth of gap junctions in the mouse heart during ontogenesis was subjected to a statistical analysis in relation to their density and junctional surface area. A mathematical method was developed to calculate the density of gap junctions (average of gap junctions per unit area) in gap junction-containing regions. The results show that there is no mathematically significant increase in gap junction density in the gap junction-containing regions. However, a significant increase during the heart development in the ratio of gap junction to plasma membrane area is demonstrated. Results are criticized in relation to the validity of the sampling process. Implications of the results in terms of the development of non-electrical and electrical communication are discussed. |
| Keywords: | Gap junctions Nexuses Mouse heart embryonic Intercellular communication |
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