基于增材制造技术修复缺损颅骨的研究和应用

该文运用增材制造技术快速制备三维重建的缺损颅骨植入体,通过对骨植入体材料对比分析,选择多孔羟基磷灰石材料应用于颅骨植入手术中。运用Mimics 10.0软件对临床计算机断层扫描(CT)影像数据重建三维植人体模型,采用增材制造技术制备多孔羟基磷灰石颅骨植入体,与颅骨贴合度好,表面光滑平顺,而多孔羟基磷灰石能够引导和诱导骨的形成,大大提高其生物相容性。增材制造技术快速制备的特点促使个性化颅骨修补植入物成为可能,个性化医用三维模型用于植入手术降低手术风险,术后效果好,具有推广应用的前景。

Study of Repairing Defective Skull Based on Additive Manufacturing and Its Application

The work selected porous hydroxyapatite （HAp） for skull surgery via comparing and analyzing the disadvantages and advantages of various implant materials. Then, the HAp was fabricated into three dimension- al implants for defective skull via additive manufacturing. We applied Mimics 10.0 software to reconstruct three di- mensional implant model based on clinical CT imaging data. Results show that the HAp implant produced via addi- tive manufacturing can fit skull well and the surface is smooth. In addition, the three dimensional porous HAp could lead and guide the formation of bone and improve the biocompatibility of implant. Additive manufacturing has the rapid preparation feature, which makes it possible to produce personalized implant of skull. Application of per- sonalized three dimensional model to implant surgery can reduce the risk of surgery and has a good post - surgical effects, which indicates that the additive manufacturing technology has promising application.