动脉化静脉皮瓣静脉瓣膜演化的实验研究

为了解动脉化静脉皮瓣中静脉瓣膜对血流的影响及其组织结构的演经,以家兔为实验动物设计制作了以与股动脉吻合的股静脉为供血血管,隐动脉为回流血管的动脉化静脉皮瓣模型,进行组织学、免疫组化和超微结构的检测。结果发现,附着于管壁的静脉瓣膜纤维组织在对血流压力的过程中出现“疲劳性”损伤、断裂,静脉瓣膜顺血流方向开放,逐渐与下方静脉管壁贴合。提示高压、快速的动脉血流对静脉瓣膜有“重塑”作用。

AN EXPERIMENTAL STUDY ON THE EVOLUTION OF VENOUS VALVES IN ARTERIALISED VENOUS FLAP

Skin flaps from rabbit thighs were raised. The saphenous veins of the flaps were anastomosed with the femoral arteries.The valves in the veins were studied histologically. Fibrous tissue of the venous valve at the site of its junction with the venous wall underwent "fatigue" injury resulting in fracture of the valve.Theraby the valve opened according to the direction of blood flow, and the valvular tissue began to adhere to the venous wall.The results suggested that rapid blood flow with high pressure might remodel the venous valve in an arterialized venous skin flap.