深部真菌感染310株及其耐药性分析

 目的了解310株深部感染真菌的菌群分布及药物敏感性状况,为临床治疗提供参考依据.方法所分离的真菌用ID3 2C鉴定真菌,用ATB FUNGUS进行药敏试验.结果310株真菌共有9种,以白色念珠菌为主.药敏结果显示,真菌对5-F胞嘧啶、两性霉素B、制霉菌素敏感率较高,均＞90%.而对咪康唑、益康唑和酮康唑的敏感率相对较低.结论深部真菌感染主要由白色念珠菌、热带念珠菌、克柔念珠菌引起.对5-F胞嘧啶、两性霉素B、制霉菌素敏感率较高,是治疗深部真菌感染首选药物.

Analysis of distribution and drug resistance of 310 fungus strains resulting in deep infections

Objective To investigate the distribution and the drug resistance of the fungi which cause deep infections.Methods The isolated fungi were identified with ID32C and drug susceptibility tests were conducted by using ATB FUNGUS.Results Totally 9 species were identified from 310 strains of deep fungi,predominantly Candida albicans.The total sensitivities of 310 strains to 5-fluorocytosine,amphotericin B,and mycomycin were >90%,but lower to miconazole,econazole,and ketoconazole.Conclusions The dominant pathogenic fungi which cause deep infection are Candida albicans,Candida tropicalis and Candida.krusei.5-Fluorocytosine,amphotericin B useful and mycomycin are most effective against the pathogenic fungi and remain to be the most drugs to treat deep infections.