| 感染细粒棘球蚴对宿主(羊)肝药酶的影响及肝组织超微结构的变化 |
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| 引用本文： | 莫红梅,薛弘燮,周宜男. 感染细粒棘球蚴对宿主(羊)肝药酶的影响及肝组织超微结构的变化[J]. 地方病通报, 2001, 16(2): 7-10,F003 |
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| 作者姓名： | 莫红梅 薛弘燮 周宜男 |
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| 作者单位： | 1. 新疆医科大学,寄生虫学教研室
2. 病理学教研室,新疆,乌鲁木齐,830054 |
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| 摘 要： | 利用生化、组化方法测定肝微粒体中细胞色素P-450、bs含量及NADPH细胞色素P-450还原酶,研究细粒棘球蚴感染对宿主（羊）肝药酶的影响及其变化规律,并对肝组织进行光镜、电镜观察。结果表明细粒棘球蚴感染可引起肝组织损伤并降低肝药酶活性,对肝药酶的抑制作用与距棘球蚴的远近呈梯度变化即距棘球蚴越近酶活性降低越明显,肝组织损伤并降低肝药酶活性,对肝药酶的抑制作用与距棘球蚴的远近呈梯度变化唧 距棘球蚴越近酶活性降低越明显。肝组织受损程度与肝药酶的活性降低程度一致,电镜下可见细凿棘球蚴周边肝细胞粗面内质网明显脱颗粒。
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| 关 键 词： | 细粒棘球蚴 羊 肝药酶 肝组织 超微结构 棘球蚴病 治疗 |
| 文章编号： | 1000-3711(2001)02-0007-04 |
Effect of Hydatid Cyst Infection on the Hepatic Drug Metabolism of Host (Sheep) and the Ultrastructural Changes of Liver |
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| MO Hong-mei,XUE Hong-xie,ZHOU Yi-nan . Teaching and Research Section of Parasitology, . Teaching and Research Section of Pathology,Xinjiang Medical University,Urumqi,Xinjiang ,China. Effect of Hydatid Cyst Infection on the Hepatic Drug Metabolism of Host (Sheep) and the Ultrastructural Changes of Liver[J]. Endemic Diseases Bulletin, 2001, 16(2): 7-10,F003 |
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| Authors: | MO Hong-mei XUE Hong-xie ZHOU Yi-nan . Teaching Research Section of Parasitology . Teaching Research Section of Pathology Xinjiang Medical University Urumqi Xinjiang China |
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| Affiliation: | MO Hong-mei,XUE Hong-xie,ZHOU Yi-nan 1. Teaching and Research Section of Parasitology, 2. Teaching and Research Section of Pathology,Xinjiang Medical University,Urumqi,Xinjiang 830054,China |
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| Abstract: | Hepatic microsomal cytochrome P-450, b5 contents and NADPHcytP-450 redutase activities have been measured by biochemical method. The results indicated that hydatid cyst infection in sheep led to the lesion of hepatic tissue and the depression of hepatic drug metabolizing function, The depression became gradually significant with the distance from hydatid cyst being shortened. The ultrastructural, the detachment of ribosome from rough endoplasmic reticulum in hepatic cell near hydatid cyst was evident. |
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| Keywords: | Echinococcus granulosus Sheep Hepatic drug metabolism Ultrastructure Liver |
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