8-羟喹啉銻对家兎心脏及肝脏功能的影响及口服后銻的吸收和排泄

在实驗所采用的剂量及条件下,正常家兔口服8-羟喹啉銻后,銻的吸收情况与酒石酸銻鉀相似.在連續口服8-羟喹啉銻14天及停药后3天內,由粪便及尿中排出的总銻量分別为口服的总銻量的64%及3%.在口服8-羟喹啉銻的前后,心电图无明显的不同,但血清酚溴酞鈉瀦留試驗的結果表明,8-羟喹啉銻对肝脏的損害比酒石酸銻鉀小.

EFFECTS OF 8-HYDROXYQUINOLINE Sb COMPLEX ON THE CARDIAC AND LIVER FUNCTIONS OF RABBITS AND THE ABSORPTION AND ELIMINATION OF ANTIMONY AFTER ORAL ADMINISTRATION

The effects of 8-Hydroxyquinoline Sb complex (8-hq·Sb) on the Cardiac and liver functions of rabbits and the absorption and elimination of antimony were studied after oral administration in a 14-day course. Tartar emetic was studied simultaneously for comparison. 8-hq-Sb or tartar emetic was administered orally to rabbits. The animals were sacrificed at different time intervals and the antimony levels in blood, liver, urine and feces were determined by a modified Maren's method. Electrocardiograms and bromsulphlein tests were carried out before medication, on the 7th and 14th days during treatment and also one week after cessation of medication. Generally speaking, the absorption of antimony in rabbits are similar for both compounds. In the 8-hq-Sb group, the elimination of antimony in feces and urine during the course of administration amounts to 64% and 3% of the total antimony administered respectively. There is no significant change in EKG before and after the administration of 8-hq-Sb. On the other hand, the BSP test seems to indicate that 8-hq-Sb causes less damage to the liver than tartar emetic.