一种新型血管生物反应器的研究与开发

目的 根据流体力学的分析改进支撑PGA-细胞材料复合物的硅胶管,设计一种应用于体外培养组织工程血管的生物反应器.方法 利用计算机仿真分析的方法对硅胶管内腔的压力场进行仿真计算,通过计算分析确定硅胶管的结构,进而开发一种新型血管生物反应器.结果 确定了硅胶管的尺寸结构以及培养室内相应的辅助结构,使整个反应器系统能够对PGA-细胞材料复合物进行动态培养.结论 改进后的硅胶管结构合理,整个血管生物反应器系统运行稳定.

Research And Development Of A Novel Blood Vessel Bioreactor

Objective To improve silicone tube which support PGA-cell material compound according to analysis of hydrodynamics to design a type of bio-reactor for tissue engineered blood vessel culture in vitro. Methods Calculated simulative inner pressure of silicone tube by simulation analysis, through calculation and analysis determined structure of silicone tube, to develop a new type of blood vessel bioreactor eventually. Results The size and structure of silicone tube and corresponding accessorial structure in inner culture chamber was determined, to make dynamic culture of PGA-cell material compound. Conclusion Improved structure of silicone tube is reasonable for stabilization of whole blood vessel bio-reactor system.