Helper-dependent adenoviral vectors for gene therapy |
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Authors: | Palmer Donna J Ng Philip |
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Affiliation: | Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA. |
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Abstract: | Helper-dependent adenoviral vectors possess a number of characteristics that make them attractive gene therapy vectors. These vectors are completely devoid of viral coding sequences and are able to mediate high-efficiency transduction in vivo to direct sustain high-level transgene expression with negligible chronic toxicity. This review focuses on advances in helper-dependent adenoviral vector technology, selected examples of in vivo studies of particular interest, and the issue of vector-mediated acute toxicity. |
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