| 马兜铃酸肾病的临床及病理表现 |
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| 引用本文： | 袁宏伟,赵春梅. 马兜铃酸肾病的临床及病理表现[J]. 中国医药指南, 2013, 0(5): 425-426 |
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| 作者姓名： | 袁宏伟 赵春梅 |
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| 作者单位： | [1]内蒙古医科大学病理学系,内蒙古呼和浩特010050 [2]内蒙古医科大学附属医院肾内科,内蒙古呼和浩特010050 |
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| 摘 要： | 目的研究马兜铃酸肾病(AAN)的临床特点、病理表现,以及影响预后的相关因素。方法回顾性分析我院2006年9月至2012年9月期间住院诊断为马兜铃酸肾病的患者36例,分析各组患者的人口学资料,临床及病理学资料,治疗经过,分析影响患者临床预后的因素。结果马兜铃酸肾病进展隐袭,表现缺乏特异性,部分患者就诊时即有肾功能不全,病理表现为中-重度肾脏小管-间质损害,炎性细胞浸润较少,可见广泛纤维化改变,部分患者在病程中出现恶性肿瘤,预后较差。结论长期服用含有马兜铃酸的药物,可引起马兜铃酸在体内的蓄积,造成肾脏,尤其是肾间质持续不可逆性损害,最终引起肾功能衰竭,也可出现恶性肿瘤。应深入研究马兜铃酸对肾脏损害的机制,寻找有效的治疗手段。
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| 关 键 词： | 马兜铃酸肾病 肾功能衰竭 |
Clinical and Pathology Research of Aristolochic Acid Nephropathy |
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| Affiliation: | YUAN Hong-wei 1, ZHAO Chu-mei2 (1 Department of Pathology, Inner Mongolia Medical University, Hohhot 010050, China; 2 Department of Nephrology, The First Affiliated Hospital of Inner Mongolia Medical University, Hohhot 010050, China) |
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| Abstract: | Objective To investigate the clinical and pathological characters of Aristolochic Acid Nephropathy patients. Methods Retrospectively analyze the clinical information and pathological character of 36 Aristolochic Acid Nephropathy patients in the deparment, during Sep 2006 to Sep 2012. Result Aristolochic Acid Nephropathy progress secretly and of non-specific, th renal pathology showed a middle to heavy tubula-interstitial nephrology, with diffuse fibrosis and a small number of inflammatory cell infiltration, malignant tumors arised in urinary system. Conclusion Long-term use of Aristolochic Acid can lead to non-reversible renal injury, and then renal function failure, malignant tumors presented in some patients. It is necessary to investigate the mechanics of Aristolochic Acid Nephropathy, and to seek the effective treatment. |
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| Keywords: | Aristolochic Acid Nephropathy（AAN） Renal failure |
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