钙通道β亚单位相关作用蛋白ahnak的研究进展

吡喹酮作为当前治疗血吸虫病的首选药物,对所有种类的血吸虫均有疗效且副作用甚微,临床应用已达30余年,但其作用机制至今尚未完全阐明.研究表明吡喹酮抗血吸虫作用与Ca~(2+)内稳态的破坏有直接关系.电压门控性钙通道(voltage-gated calcium channels,VGCC)为Ca~(2+)的内流提供通道,并已有研究者提出了"血吸虫钙通道-吡喹酮作用靶点"假说.研究显示ahnak蛋白与钙通道β亚单位结合能增加Ca~(2+)内流,该文围绕ahnak蛋白的基本结构、功能以及ahnak/β亚单位之间的相互作用及功能等方面的研究进展作一综述,为探讨吡喹酮抗血吸虫的机制提供一定的参考价值.

Research progress on ahnak,β subunit of calcium channels-associated protein

Praziquantel is the current drug of first choice for schistosomiasis.It is highly effective against all species of schistosomes and shows minimal adverse effects.Though the drug has been introduced for treatment of schistosomiasis for more than 30 years,the parasite-elimination mechanism of praziquantel remains unclear.The effect of praziquantel against schistosomes is thought to be directly linked to the disruption of Ca~(2+)homeostasis.Voltage-gated calcium channels(VGCC)provide the pathway for Ca~(2+) influxes into cells,described as the hypothesis of "Ca~(2+) channels as targets of praziquantel".This paper focused on the structure and function of ahnak,with particular emphasis on the interaction with β subunits of calcium channels.