Serum concentration of granulocyte colony stimulating factor in term and preterm infants |
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| Authors: | Chirico G Ciardelli L Cecchi P Amici M De Gasparoni A Rondini G |
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| Institution: | (1) Divisione di Patologia Neonatale, Policlinico San Matteo, I-27100 Pavia, Italy Tel.: +39 382 502929, Fax: +39 382 502802, E-mail: chirico@venus.it, IT;(2) Research Laboratories, Policlinico San Matteo, IRCCS Pavia, Italy, IT;(3) Department of Paediatrics, University of Pavia, Italy, IT |
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| Abstract: | We measured serum granulocyte colony stimulating factor (GCSF) concentration and absolute neutrophil count in four groups
of infants: (1) 15 healthy term newborn infants; (2) 21 healthy preterm newborn infants, with mean (SD) birth weight 1583
(533) g, and gestational age 32.0 (3.8) weeks; (3) 5 infected newborn infants; (4) 22 6-month-old control infants. Median
(range) serum GCSF concentration was 132.2 (41.5–176.0) pg/ml in term infants, 51.5 (1.8–175.7) pg/ml in preterm infants and
138.9 (54.1–449.8) pg/ml in 6-month-old control infants, with a significant reduction in preterm infants, as compared to term
and control infants. GCSF levels were significantly higher in the infected infants, as compared to healthy neonates.
Conclusion A significant positive relationship was found in term and preterm infants between serum GCSF concentration and gestational
age or birth weight. No relationship was found between serum GCSF concen tration and neutrophil count. The low GCSF baseline
levels may contribute to the increased incidence and severity of infection in preterm infants.
Received: 17 May 1996 and in revised form: 20 July 1996 / Accepted: 29 July 1996 |
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| Keywords: | Granulocyte colony stimulating factor Infection Neutrophil count Newborn infants |
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