YMDD变异的慢性乙型肝炎的临床与病理研究

目的探讨YMDD变异的慢性乙型肝炎的临床特点及病理改变，提高治疗YMDD变异的慢性乙型肝炎的疗效。方法将2003年6月-2006年5月住院的60例发生YMDD变异的慢性乙型肝炎资料进行分析。结果发生YMDD变异的慢性乙型肝炎患者肝损害以轻、中度为主；病理改变G1占38．880h，（7／18），G2占22．22％（4／18），G3占27．77％（5／18），G4占11．11％（2／18）；变异后采用阿德福韦、干扰素、恩替卡韦继续抗病毒治疗愈后好：肝硬化患者变异时停药易导致病情加重、不可逆转。结论发生YMDD变异的慢性乙型肝炎病情大多可逆转．继续抗病毒治疗愈后良好

Clinical and pathological research of YMDD variation in chronic hepatitis B

Objective To study the clinical features and pathological changes in YMDD variation of Chronic hepatitis B,and improve the clinicians' abilities while dealing with the YMDD variation of chronic hepatitis B.Method 60 cases of in-patient chronic hepatitis B that had experienced the YMDD variation during the period from June 2003 to May 2006 were analysed.Result Most of YMDD variation occured in chronic hepatitis B patients with mild or moderate liver function impairment.According to pathological change,the ratio of G1,G2,G3,and G4 was 38.88%(7/18),22.22%(4/18),27.77%(5/18),and 11.11%(2/18) respectively.YMDD variation patient who got substituted antivirus therapy had better prognosis.For liver cirrhosis patient,YMDD variation could lead to sever and irreversible deterioration of liver function.Conclusion Liver function deterioration caused by YMDD variation in chronic patient was most reversible.The prognosis was good while substitute antivirus therapy was given.