| 一氧化氮合酶在继发癫痫的脑膜瘤中表达及其生物学意义 |
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| 引用本文： | 杨珉,陈坚.一氧化氮合酶在继发癫痫的脑膜瘤中表达及其生物学意义[J].中国临床神经外科杂志,2003,8(6):420-422. |
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| 作者姓名： | 杨珉 陈坚 |
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| 作者单位： | 1. 扬州市第一人民医院神经外科,江苏扬州,225001
2. 华中科技大学同济医学院附属同济医院神经外科,湖北武汉,430022 |
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| 摘 要： | 目的探讨一氧化氮在脑膜瘤继发癫痫的发病机制中的作用。方法运用SABC免疫组化方法研究了一氧化氮合酶三种亚型在继发术前癫痫的脑膜瘤标本中的表达。结果在实验组与对照组脑膜瘤的组织切片中,诱生型一氧化氮合酶(iNOS)表达有非常显著性差异(P<0.01),神经元型一氧化氮合酶(nNOS)的表达有显著性差异(P<0.05),内皮组织型一氧化氮合酶(eNOS)的表达没有统计学意义(P>0.05)。结论一氧化氮参与了脑膜瘤继发的术前癫痫发作病理过程,iNOS是诱发脑膜瘤继发术前癫痫的内源性一氧化氮的主要合酶,nNOS可以增强iNOS的诱导作用。
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| 关 键 词： | 一氧化氮 一氧化氮合酶 脑膜瘤 癫痫 生物学意义 |
| 文章编号： | 1009-153X(2003)06-0420-03 |
| 修稿时间： | 2003年3月18日 |
Expression of Nitric Oxide Synthases in Meningiomas Complicated by Epilepsy and It's Biological Significance |
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| YANG Min ,CHEN Jian.Expression of Nitric Oxide Synthases in Meningiomas Complicated by Epilepsy and It''''s Biological Significance[J].Chinese Journal of Clinical Neurosurgery,2003,8(6):420-422. |
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| Authors: | YANG Min CHEN Jian |
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| Institution: | YANG Min *,CHEN Jian.* Department of Neurosurgery,Yangzhou First People's Hospital,Yangzhou Jiangsu225001,China |
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| Abstract: | Objective To investigate the role of nitric oxide in the pathogenesis of the preoperative epilepsy secondary to meningioma.Method The expression of nitric oxide synthases(NOS)in the meningiomas complicated by the preoperative epilepsy was detected by SABC immunohistochemical technique.Results There were significant differences in the expressions of iNOS(P<0.01)and nNOS(P<0.05),and insignificant difference in the eNOS expression(P>0.05)between both the experimental group and control group.Conclusions Maybe nitric oxide takes part in the pathogenesis of the preoperative epilepsy secondary to meningiomas.The iNOS is a main synthase of endogenic nitric oxide which probably induced the eplipsy secondary to meningiomas.The nNOS can enhance the induction of iNOS. |
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| Keywords: | Nitric oxide Nitric oxide synthases Meningiomas Epilepsy Biological significance |
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