| 荆芥内酯平衡溶解度和油水分配系数的测定 |
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| 引用本文： | 朱慧,耿婷,张丽,单鸣秋,丁安伟. 荆芥内酯平衡溶解度和油水分配系数的测定[J]. 中国中药杂志, 2010, 35(23): 3144-3146 |
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| 作者姓名： | 朱慧 耿婷 张丽 单鸣秋 丁安伟 |
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| 作者单位： | 南京中医药大学,江苏省方剂研究重点实验室,江苏,南京,210046 |
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| 基金项目： | 国家"重大新药创制"科技重大专项(2009ZX09103-339) |
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| 摘 要： | 目的:测定荆芥内酯的平衡溶解度和在正辛醇-水/缓冲液体系中的表观油水分配系数。方法:采用HPLC法测定荆芥内酯在水和各种有机溶剂中的平衡溶解度;采用摇瓶法测定荆芥内酯在正辛醇-水/缓冲液体系中的表观油水分配系数。结果:25℃时荆芥内酯在水中的平衡溶解度为910 mg.L-1,常用有机溶剂甲醇对荆芥内酯的溶解性较好,为93 855 mg.L-1;25℃时荆芥内酯的正辛醇-水的表观分配系数为49.35(lnKow=1.69)。结论:荆芥内酯在石油醚中几乎不溶,在水中的平衡溶解度较低,在甲醇中的平衡溶解度较高,在酸性至中性磷酸盐缓冲溶液中的表观分配系数变化不大,碱性条件下的表观分配系数明显下降。
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| 关 键 词： | 荆芥内酯 平衡溶解度 表观油水分配系数 |
| 收稿时间： | 2010-08-05 |
Determination of equilibrium solubility and apparent oil/ water partition coefficient of schizonepetin |
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| ZHU Hui,GENG Ting,ZHANG Li,SHAN Mingqiu and DING Anwei. Determination of equilibrium solubility and apparent oil/ water partition coefficient of schizonepetin[J]. China Journal of Chinese Materia Medica, 2010, 35(23): 3144-3146 |
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| Authors: | ZHU Hui GENG Ting ZHANG Li SHAN Mingqiu DING Anwei |
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| Affiliation: | Nanjing University of Chinese Medicine, Key Laboratory for Modern Research of Traditional Chinese Medical Formulae of Jiangsu, Nanjing 210046, China;Nanjing University of Chinese Medicine, Key Laboratory for Modern Research of Traditional Chinese Medical Formulae of Jiangsu, Nanjing 210046, China;Nanjing University of Chinese Medicine, Key Laboratory for Modern Research of Traditional Chinese Medical Formulae of Jiangsu, Nanjing 210046, China;Nanjing University of Chinese Medicine, Key Laboratory for Modern Research of Traditional Chinese Medical Formulae of Jiangsu, Nanjing 210046, China;Nanjing University of Chinese Medicine, Key Laboratory for Modern Research of Traditional Chinese Medical Formulae of Jiangsu, Nanjing 210046, China |
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| Abstract: | |
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| Keywords: | schizonepetin equilibrium solubility apparent oil/water partition coefficient |
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