| 西妥昔单抗联合化疗或放疗治疗晚期头颈鳞癌的疗效评价 |
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| 引用本文： | 李金忠,郑家伟,张志愿. 西妥昔单抗联合化疗或放疗治疗晚期头颈鳞癌的疗效评价[J]. 上海口腔医学, 2008, 17(1): 1-5 |
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| 作者姓名： | 李金忠 郑家伟 张志愿 |
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| 作者单位： | 上海交通大学医学院附属第九人民医院·口腔医学院,口腔颌面外科,上海,200011 |
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| 基金项目： | 上海市重点学科建设项目 |
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| 摘 要： | 表皮生长因子受体在头颈鳞状细胞癌广泛表达,而且其表达水平与预后呈负相关.因此作为一种表皮生长因子受体抑制剂,Cetuximab在治疗头颈鳞癌中的研究受到广泛关注.大量的临床试验对Cetuximab联合化疗或放疗治疗晚期头颈鳞癌的方案进行了评价.本文对这些方案中Cetuximab的疗效进行评价,以期对该药的临床应用及晚期头颈鳞癌的治疗提供参考.
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| 关 键 词： | 西妥昔单抗 头颈鳞癌 表皮生长因子受体 Cetuximab Squamous cell carcinoma of head and neck Epidermal growth factor receptor 西妥昔单抗 联合化疗 放疗治疗 晚期 头颈鳞癌 疗效评价 neck head squamous cell carcinoma advanced chemotherapy radiotherapy combination Supported Shanghai Academic Discipline Project article reviews |
| 文章编号： | 1006-7248（2008）01-0001-05 |
| 收稿时间： | 2007-08-15 |
| 修稿时间： | 2007-12-11 |
Evaluation of Cetuximab in combination with radiotherapy or chemotherapy against advanced squamous cell carcinoma of the head and neck |
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| LI Jin-zhong,ZHENG Jia-wei,ZHANG Zhi-yuan. Evaluation of Cetuximab in combination with radiotherapy or chemotherapy against advanced squamous cell carcinoma of the head and neck[J]. Shanghai journal of stomatology, 2008, 17(1): 1-5 |
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| Authors: | LI Jin-zhong ZHENG Jia-wei ZHANG Zhi-yuan |
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| Abstract: | Cetuximab is an epidermal growth factor receptor inhibitor which has been recently focused on the therapy of squamous cell carcinoma of the head and neck based on the nearly universal expression of this protein, the negative prognostic associations with expression and robust preclinical data. Clinical trials to date have demonstrated modest activity of this drug in combination with chemotherapy or radiotherapy against advanced squamous cell carcinoma of the head and neck. This article reviews the progress in utilization of cetuximab in advanced squamous cell carcinoma of the head and neck. |
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| Keywords: | Cetuximab Squamous cell carcinoma of head and neck Epidermal growth factor receptor |
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