微创穿刺术治疗高血压脑出血时间窗的研究

目的:研究微创穿刺术治疗高血压脑出血的最佳时机.方法:41例高血压脑出血随机分为4组,即手术距发病时间<6 h组、6～12 h组、12～18 h组和18～24 h组;用再出血率、近期疗效、远期疗效、病死率、转归优良率等疗效评价指标进行组间比较.结果:再出血等并发症发生率无显著差异;3个月时的临床转归优良率:<6 h组>6～12 h组和12～18 h组>18～24 h组(P<0.05),18～24 h组病死率最高,达30%(3/10).结论:高血压脑出血发病后6 h内是微创穿刺术治疗的最佳时机.

Treatment of Hypertensive Intracerebral Hemorrhage by Minimal Invasive Puncture:A Time Window Study

Objective:To study the best opportunity for minimal invasive puncture in the treatment of hypertensive intracerebral hemorrhage.Methods:Forty-one patients with hypertensive intracerebral hemorrhage were randomly divided into four groups:<6 h,6-12 h,12-18 h and 18-24 h from the onset of symptoms.The comparison among groups in outcome measures were performed,including the rebleeding rate,short-term efficacy,long-term efficacy,mortality,and excellent and good rate.Results:The incidence of complication such as rebleeding etc had no significantly difference in the four groups.The excellent and good rates of clinical outcomes at 3 months were the<6 h group>6-12 h group,and 12-18 h group>18-24 h group(P<0.05).The 18-24 h group had the highest mortality(30%,3/10).Conclusions:Within 6 h after the onset of hypertensive intracerebral hemorrhage was the best opportunity for the minimal invasive puncture.