| 川芎嗪注射液对大鼠肾小球系膜细胞增生的影响 |
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| 引用本文： | 肖建武,易著文,吴小川. 川芎嗪注射液对大鼠肾小球系膜细胞增生的影响[J]. 医药导报, 2004, 23(9): 0611-0613 |
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| 作者姓名： | 肖建武 易著文 吴小川 |
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| 作者单位： | 1. 湖南省湘潭卫生学校儿科教研组,411100
2. 中南大学湘雅医学院附属第二医院小儿肾脏病研究室,长沙,410011 |
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| 基金项目： | 国家自然科学基金资助项目 (基金编号 :3 980 0 14 0 ) |
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| 摘 要： | 目的：探讨川芎嗪注射液(TMP)对大鼠肾小球系膜细胞增生的作用。方法： 在体外培养的大鼠肾小球系膜细胞(GMCs)株中加入脂多糖(LPS)后，再分别加入不同浓度的TMP，设实验组：GMCs＋LPS＋TMP，对照组即GMCs＋LPS组及GMCs组。采用四甲基偶氮唑蓝液(MTT)掺入方法，于24，48 h观察3组中GMCs增生率。结果： 实验组于48 h时对GMCs增生的抑制最为显著，实验组GMCs增生率明显低于GMCs＋LPS组及GMCs组(P＜0.01)。结论：TMP能明显抑制大鼠GMCs增生。
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| 关 键 词： | 川芎嗪 系膜细胞 大鼠 |
| 文章编号： | 1004-0781(2004)09-0611-03 |
| 修稿时间： | 2003-10-27 |
Effect of Tetramethylpyrazine Injection on Proliferation of Glomerulus Mesangium Cells in Rats |
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| XIAO Jian-wu ,YI Zhu-wen ,WU Xiao-chuan. Effect of Tetramethylpyrazine Injection on Proliferation of Glomerulus Mesangium Cells in Rats[J]. Herald of Medicine, 2004, 23(9): 0611-0613 |
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| Authors: | XIAO Jian-wu YI Zhu-wen WU Xiao-chuan |
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| Affiliation: | XIAO Jian-wu 1,YI Zhu-wen 2,WU Xiao-chuan 2 |
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| Abstract: | Objective:To explore the inhibitory effect of tetramethylpyrazine (TMP) on proliferation of glomerulus mesangial cells (GMCs) in rats. Methods:Rat GMCs lines were cultured in vitro, Lipoplysa ccharide (LPS) and TMP with different concentration were added in the culture me dium. There were three experimental groups, GMCs+LPS+TMP,GMCs+LPS, and GMCs named as group TMP,LPS and GMCs, respectively. GMCs proliferative rate was dete rmined by MTT. Results:In TMP group,the GMCs proliferative rate were s ignificantly lower than in LPS group or in GMCs group (P<0.01). Conclusion:It suggests that TMP can effectively inhibit the proliferation of GMCs. |
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| Keywords: | Tetramethylpyrazine Mesangial cell Rats |
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