嗜铬细胞瘤患者血浆心钠素及内源性类洋地黄物质的变化及其意义

采用心钠素(ANP)及内源性类洋地黄物质(EDLC)放射免疫分析法,观察了38例嗜铬细胞瘤在高血压状态、非高血压状态及肿瘤切除后血浆ANP及EDLC的变化及与血压、尿儿茶酚胺的关系。结果表明,该病患者于高血压状态时血浆ANP明显高于正常人和非高血压状态(P<0.01),而肿瘤切除后则接近正常。高血压状态时血浆ANP与血压及尿儿茶酚胺呈正相关。高血压状态时血浆EDLC水平明显低于正常人,且与血浆ANP、血压、尿儿茶酚胺均呈负相关,而非高血压状态及手术后恢复正常或接近正常。

CHANGES OF PLASMA ANP AND EDLC IN PATIENTS WITH PHEOCHROMOCYTOMA

Plasma atrial natriuretic peptides (ANP) and endogenous digoxin-like compounds (EDLC) in 38 patients with pheo-chromocytoma were measured by radioimmunoassay. The results showed that the mean plasma ANP in these patients during hypertension was significantly higher than in the normal controls (P<0.01). The mean plasma ANP of the patients during normotensive state was lower than that during hypertension (P<0.01). After the tumors were removed, the plasma ANP levels returned to near normal. The levels of plasma ANP were found to be positively correlated with blood pressure and urinary catecholamine during hypertension. The results also showed that the average level of plasma EDLC of the patients during hypertension was lower than that in the normal controls (P<0.01). After pheochromo-cytomas being removed or during the stage of normotension, the average level of plasma EDLG returned to normal or near normal level. The levels of plasma EDLG were found to be negatively correlated with plasma ANP, blood pressure and urinary catecholamine.