PET-CT在调强适形放疗中的临床应用

PET技术的快速发展使其在肿瘤分期和放疗计划(RTP)的制定中拥有了更大的应用空间。PET可以得到更多的肿瘤生物学信息(如肿瘤细胞密度、对射线敏感情况等信息),该生物学信息与CT或MRI的解剖学信息一起,为在放疗中锁定肿瘤细胞提供新的思路。以PET-CT为基础的调强适形放疗(IMRT),充分利用融合技术显示解剖生理靶区的能力,并在放疗计划中引入了生物靶区的概念。从理论上说,以PET-CT为基础的IMRT能在18F-氟代脱氧葡萄糖(18F-FDG)高代谢区提高最大日照射剂量,从而取得更好的疗效。因此,PET-CT的肿瘤诊断技术和IMRT共同开拓了最佳生物放疗新领域。

Clinical application of PET-CT in intensive modulated radiotherapy

The technology of PET had developed rapidly, and made it more and more important in stage and radiotherapy of tumor. The results of PET can give some biological information, such as the density of tumor and the sensitiveness to radiotherapy, these information together with the morphologic modalities, for example CT and MRI, offer a new opportunity to target the tumor cell in the therapy. Intensive Modulated Radiotherapy based on PET-CT, have the ability to display the biologic target through the fusion image of PET and CT, and create the concept of biologic target volume. In theory, within the high metabolic region of fluorideoxyglucose, you can apply a higher appropriate daily radiotherapy dose for better result. So the tumor diagnostic technology of PET-CT and IMRT bring a new biologic radiotherapy into reality.