| 拟除虫菊酯对大鼠脑突触体谷氨酸摄取功能的影响 |
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| 引用本文： | 吴建平,夏若寒.拟除虫菊酯对大鼠脑突触体谷氨酸摄取功能的影响[J].卫生研究,1999,28(5):261-262. |
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| 作者姓名： | 吴建平 夏若寒 |
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| 作者单位： | 同济医科大学环境医学研究所!武汉430030 |
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| 摘 要： | 作者观察了拟除虫菊酯对大鼠脑突触体谷氨酸重摄取功能的影响。在一定量的突触体与不同剂量的氯氰菊酯或氯菊酯中加入放射性标记谷氨酸，测定突触体摄取的谷氨酸的放射活性，在１０－ ９ ～１０－ ４ ｍ ｏｌ／ Ｌ的剂量范围内，氯氰菊酯及氯菊酯明显抑制突触体对谷氨酸的重摄取量，并有一定的剂量依赖性。在相同剂量水平，氯氰菊酯作用明显强于氯菊酯。结果表明拟除虫菊酯对大鼠脑突触体谷氨酸高亲和性重摄取功能有抑制作用，提示突触体谷氨酸重摄取系统功能障碍在拟除虫菊酯兴奋性神经毒性中具有重要意义。
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| 关 键 词： | 拟除虫菊酯 突触体 谷氨酸 重摄取 |
Effects of pyrethroids on the glutamate uptake system in synaptic vesicle of rats |
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| Wu Jianping,Xia Ruohan,Shi Nian,Liu Yugu Institute of Environmental Toxicology,Tongji Medical University,Wuhan ,China.Effects of pyrethroids on the glutamate uptake system in synaptic vesicle of rats[J].Journal of Hygiene Research,1999,28(5):261-262. |
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| Authors: | Wu Jianping Xia Ruohan Shi Nian Liu Yugu Institute of Environmental Toxicology Tongji Medical University Wuhan China |
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| Institution: | Institute of Environmental Toxicology, Tongji Medical University, Wuhan 430030, China. jpwu@dns.njmu.edu.cn |
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| Abstract: | In order to study the effects of cypermethrin and permethrin insecticides on the glutamate uptake of rat brain, brain synaptic vesicles and cypermethrin or permethrin were incubated with 3H-glutamate (37 KBq, 1 mumol/L). The radio activity was detected by a liquid scintillation counter. The results showed that cypermethrin and permethrin in the concentration of 10(-9)-10(-4) mol/L could inhibit the high affinity uptake of glutamate in the synaptosomes of cerebral cortex, hippocampus and striatum in a dose-response manner. Cypermethrin was more powerful than permethrin at the same dose. It was concluded that glutamate uptake inhibition might play a vital role in the neurotoxicity induced by pyrethroid insecticides. |
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| Keywords: | pyrethroid synaptosome glutamate uptake$$$$ |
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