HE4和CA125检测与病理学分类在罗同巢癌诊断中的相关性研究

目的探讨人血清附睾蛋白4（HE4）和糖蛋白抗原125（CAl25）在卵巢恶性肿瘤诊断中与病理学分类的符合率，同时探讨以上两种标记物对卵巢癌的灵敏度和特异性。方法将研究对象通过病理切片分为卵巢癌确认~H（50例1，卵巢良性病变组f50例1。健康妇女（50例1．同时用化学免疫发光的方法检测上述对象的HE4及CAl25血清浓度。结果在卵巢恶性病变过程中，通过病理确诊是否患卵巢癌，CAl25对卵巢癌病人的灵敏度和特异性分别为57％和68％，HE4对患卵巢癌各期的灵敏度和特异性为94％和96％。结论HE4在卵巢癌患者中高表达。与病理结果符合率较高：CAl25在卵巢癌灵敏度特异性低．与病理诊断符合率低．且CAl25对早期卵巢癌患者存在着一定的误诊漏诊，HE4是比CAl25更能反映患卵巢癌的一个指标。

Correlation between the level of HE4, CA125 and pathalogical classification in the diagnosis of ovarian cancer

Objective To investigate the coincidence rate between human serum epididymis protein 4 （HE4）, glycoprotein antigen 125 （CA125） levels and the pathologic resuhs in the diagnosis of ovarian cancer, and explore the sensitivity and specificity of I-IE4 and CA125 in ovarian cancer diagnosis. Methods According to biopsy results, 150 cases was divided into ovarian cancer group （50 cases）, benign ovarian lesions group （50 cases） and healthy women group （50 cases）. The serum HE4 and CA125 con- centrations of all cases were detected by chemiluminescenceimmunoassay. Results In the process of malignant ovarian lesions, pathology was the diagnostic method. The sensitivity and specificity of CA125 for ovarian cancer were 57% and 68%, and that of HE4 were 94% and 96%. Conclusion HE4 is high expressed in ovarian cancer patients and has nice coincidence rate with patho- logic results. However, CA125 gets low sensitivity and specificity, and has low coincidence rate with pathological results. In addi- tion, CA125 may make misdiagnosis for early ovarian cancer patients. HE4 is a better marker for ovarian cancer than CA125.