胆原性脓毒症时动脉血酮体比值与肝细胞能量状态的关系

为分析实验性胆原性脓毒症时动脉血酮体比与肝能量代谢改变之间的关系，借助兔自身对照性动物模型，对胆原性脓毒症状下肝脏线粒体呼吸功能，肝组织ＡＴＰ含量及ＡＫＢＲ进行了动态检测。

Relationship between arterial ketone body ratio and energy status of hepatocytes in biliary sepsis in rabbits

The relationship of arterial ketone body ratio(AKBR)with the changes of energy metabolism of hepatocytes was studied in a rabbit model of biliary sepsis in which hepatic mitochondrial function and adenosine triphosphate(ATP)content were determined in the 12th, 24th and 48th h after the initiation of fbiliar sepsis,Respiratory impairment of hepatic mitochondria was demonstrated in the infected lobe in the 12th h after septic challenge by showing rapid decrease of state 3 respiratory rate,respiratory control ratio(RCR)and P/O ratio of the isolated mitochondria and a reduction of tissue ATP content.The decrease and the reduction became more severe when biliary sepsis advanced.AKBR was decreased continuously from the 12th h after sepsis when increased activity of RCR was shown in the non-infected liver lobes and RCR in the infected lobes was significantly lowered which was further lowered as sepsis went on.Our findings suggest that AKBR can serve as a sensitive indicator for the early hepatic metabolic derangement in biliary sepsis.