| ~(125)I粒子植入治疗恶性脑胶质瘤 |
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| 引用本文： | 袁绍纪,吕学明,孙希炎,杜池刚,朱伟杰,卢培刚,张荣伟,于峰,吕福林.~(125)I粒子植入治疗恶性脑胶质瘤[J].中国微侵袭神经外科杂志,2011(11). |
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| 作者姓名： | 袁绍纪 吕学明 孙希炎 杜池刚 朱伟杰 卢培刚 张荣伟 于峰 吕福林 |
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| 作者单位： | 济南军区总医院神经外科; |
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| 摘 要： | 目的探讨125I粒子植入在恶性脑胶质瘤治疗中的作用。方法将46例经组织细胞学确诊的复发恶性胶质瘤病人随机分成2组:125I组21例,手术切除复发肿瘤且术中植入125I粒子;对照组25例,手术切除复发肿瘤加或不加去骨瓣减压。两组术后均采用尼莫司汀辅助化疗。结果125I组肿瘤全切除15例,次全切除3例,部分切除3例;对照组肿瘤全切除17例,次全切除4例,部分切除4例。术后并发症125I组9例,对照组8例,均经保守治疗治愈。随访6～36个月,125I组中位生存时间8.0个月,平均生存时间8.9个月,6个月累积生存率56.0%,12个月累积生存率31.4%;对照组中位生存时间4.0个月,平均生存时间5.4个月,6个月累积生存率16.8%,12个月累积生存率2.9%;两组生存时间和生存率差异均有统计学意义(P<0.05)。结论125I粒子植入治疗恶性脑胶质瘤疗效确切,且无明显副作用,是一种安全、有效的治疗方法。
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| 关 键 词： | 神经胶质瘤 近距离放射疗法 神经外科手术 药物疗法 |
Role of ~(125)I implantation in the treatment of malignant gliomas |
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| Yuan Shaoji,Lv Xueming,Sun Xiyan,Du Chigang,Zhu Weijie,Lu Peigang,Zhang Rongwei,Yu Feng,Lv Fulin.Role of ~(125)I implantation in the treatment of malignant gliomas[J].Chinese Journal of Minimally Invasive Neurosurgery,2011(11). |
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| Authors: | Yuan Shaoji Lv Xueming Sun Xiyan Du Chigang Zhu Weijie Lu Peigang Zhang Rongwei Yu Feng Lv Fulin |
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| Institution: | Yuan Shaoji,Lv Xueming,Sun Xiyan,Du Chigang,Zhu Weijie,Lu Peigang,Zhang Rongwei,Yu Feng,Lv Fulin Department of Neurosurgery,General Hospital of Ji'nan Command,Ji'nan,Shandong 250031,China |
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| Abstract: | Objective To explore the role of 125I seed implantation in the treatment of malignant gliomas.Methods Forty-six patients with malignant glioma recurrence confirmed by histocytology were randomly divided into 125I group(n=21) and control groups(n=25).Tumor resection and 125I seed implantation were performed in 125I group,and tumor resection with or without decompressive craniectomy was done in control group.Adjuvant chemotherapy with Nimustine was given after surgery.Results Total tumor resection was achieve... |
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| Keywords: | glioma brachytherapy neurosurgical procedures drug therapy |
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