370例肿瘤患者用药不良反应报告分析

目的调查分析肿瘤患者用药不良反应发生规律及特点。方法收集我院370例药品不良反应报告,按患者性别、年龄、给药途径、药品不良反应临床表现、涉及的器官或系统、涉及药品、因果评价及转归、报告质量等因素进行回顾性统计分析。结果药品不良反应涉及中老年人最多,抗感染类药的不良反应发生率居首位,其次为抗肿瘤药、中药注射剂和生物制品;静脉给药为主要途径;紫杉醇、奥沙利铂、氟尿嘧啶、巴曲亭、高聚生可导致严重不良反应。结论加强药品不良反应的监测和报告工作是提高临床用药安全的重要内容,尤其应对易引发严重不良反应的药品进行重点监测。

Analysis of 370 Adverse Drug Reaction Reports of Tumor Patients

Objective To discuss the characteristics and regularities of adverse drug reactions（ADR） of tumor patients in our hospital. Methods ADR reports of 370 cases collected were analyzed statistically in respect of patients＂ age and sex, clinical manifestations, routes of administration, ADR-involved organs or systems, the involved drugs and rating of correlated factors and outcome etc. Results The reports displayd that the middle and old aged people were the main part in the patients. Anti-infective drugs dominted the first place on the list of ADR. incidence rate, followed by antineoplastic agent and Chinese patent medicines and biologicals, and drugs for Intravenous route administration resulted in the highest rate. Incidence rate of severe ADIL induced by paclitaxel, fluorouracil and oxaliplatin occupied the front 3 places in the sequence. Conclusion The monitoring and report of ADIL are the important occupation in order to ensure and promote safe and rational administration, and more attention should be paid to the drugs which induced the severe ADIL.