Low frequency stimulation of the pedunculopontine nucleus modulates electrical activity of subthalamic neurons in the rat |
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Authors: | Annamaria Capozzo Tiziana Florio Giuseppina Confalone Daniela Minchella Paolo Mazzone Eugenio Scarnati |
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Affiliation: | (1) Department of Biomedical Sciences and Technologies, University of L’Aquila, L’Aquila, Italy;(2) Unit of Functional and Stereotactic Neurosurgery, CTO Hospital, Via S. Nemesio, Rome, Italy |
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Abstract: | Electrical stimulation of the rat pedunculopontine nucleus (PPTg) (<25 Hz) synchronized firing of subthalamic neurons (STN) with each stimulus, and a continuous irregular activity often preceded recovery of burst discharges in control as well as in 6-hydroxydopamine lesioned animals. Firing was blocked both by increasing frequency of stimulation (>50 Hz) and current intensity (>500 μA). The data suggest that clinically relevant frequencies for PPTg deep brain stimulation in Parkinson’s disease modulate burst discharges in STN neurons. |
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Keywords: | DBS Basal ganglia 6-Hydroxydopamine Parkinson’ s disease |
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