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Low frequency stimulation of the pedunculopontine nucleus modulates electrical activity of subthalamic neurons in the rat
Authors:Annamaria Capozzo  Tiziana Florio  Giuseppina Confalone  Daniela Minchella  Paolo Mazzone  Eugenio Scarnati
Affiliation:(1) Department of Biomedical Sciences and Technologies, University of L’Aquila, L’Aquila, Italy;(2) Unit of Functional and Stereotactic Neurosurgery, CTO Hospital, Via S. Nemesio, Rome, Italy
Abstract:Electrical stimulation of the rat pedunculopontine nucleus (PPTg) (<25 Hz) synchronized firing of subthalamic neurons (STN) with each stimulus, and a continuous irregular activity often preceded recovery of burst discharges in control as well as in 6-hydroxydopamine lesioned animals. Firing was blocked both by increasing frequency of stimulation (>50 Hz) and current intensity (>500 μA). The data suggest that clinically relevant frequencies for PPTg deep brain stimulation in Parkinson’s disease modulate burst discharges in STN neurons.
Keywords:DBS  Basal ganglia  6-Hydroxydopamine  Parkinson’  s disease
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