| 肝细胞癌与乙型肝炎病毒基因变异关系研究进展 |
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| 引用本文： | 郝伏龙,缪辉来.肝细胞癌与乙型肝炎病毒基因变异关系研究进展[J].国际外科学杂志,2009,36(4). |
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| 作者姓名： | 郝伏龙 缪辉来 |
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| 作者单位： | 广东医学院附属医院肝胆外科,广州,524023 |
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| 摘 要： | 乙型肝炎病毒(HBV)是肝细胞癌(hepatocellular carcinoma,HCC)的主要病因,研究发现HBV基因变异与HCC的发生过程关系密切.本文从病因学方面对乙型肝炎病毒致肝癌的主要机制作一综述.HBV基因有4个开放读码区(S、C、P、X区),主要通过点突变、插入、截短变异等方式与HCC发生相关.
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| 关 键 词： | 乙肝病毒 基因变异 肝细胞癌 |
Progress on the association between hepatitis B virus and hepatocellular carcinoma |
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| HAO Fu-Long,MIAO Hui-Lai.Progress on the association between hepatitis B virus and hepatocellular carcinoma[J].International Journal of Surgery,2009,36(4). |
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| Authors: | HAO Fu-Long MIAO Hui-Lai |
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| Abstract: | Chronic hepatitis B virus is the most common cause of hepatocellular carcinoma. This article summarizes the pathogenesis of HBV-related carcinogenesis and the viral and host factors that may increase the risk of HCC development. HBV has 40RFs (S,C,P,X). The approach associated with HBV-related hepatocarcinogenesis includes paint mutation, insertion mutation and deletion mutations. |
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| Keywords: | hepatitis B virus genetic mutation hepatocellular carcinoma |
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