Primary Ewing sarcoma/PNET of the kidney: fine-needle aspiration, histology, and dual color break apart FISH Assay |
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Authors: | Kang Steven H Perle Mary Ann Nonaka Daisuke Zhu Hongfa Chan Wai Yang Grace C H |
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Affiliation: | Department of Pathology, New York University Medical Center, New York, New York, USA. |
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Abstract: | A 34-year-old previously healthy Hispanic man presented with lower back pain. CT scan revealed an 8-cm space-occupying lesion in the superior pole of the left kidney with numerous small lytic lesions in the skull, vertebrae, ribs, and pelvic bones. CT-guided fine-needle aspiration biopsy revealed a high-grade primitive small round cell tumor with the tumor cells being strongly positive for CD99 and vimentin. The patient subsequently underwent a left nephrectomy. Fluorescence in situ hybridization analysis using a DNA probe for the Ewing Sarcoma breakpoint region 1 (EWSR1) on chromosome 22g12 revealed a rearrangement of the EWSR1 locus. The diagnosis of primary Ewing sarcoma/primitive neuroectodermal tumor of the kidney was established. |
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Keywords: | primary Ewing sarcoma/PNET of the kidney extraskeletal Ewing sarcoma cytology fine-needle aspiration dual break apart FISH |
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