TPO-Ab在甲状腺自身免疫性疾病中的应用

目的：探讨甲状腺过氧化物酶抗体（TPO-Ab）在甲状腺功能亢进（甲亢）、甲状腺功能减退（甲减）、单纯性甲状腺肿大患者的临床价值。方法：采用放射免疫分析检测甲状腺疾病患者血清TGA、TMA、TPO-Ab浓度及血清FL、FT4、TSH水平，分析TPO-Ab在69例甲亢、53例甲减及45例单纯性甲状腺肿的阳性率。结果：TPO-Ab的阳性率（82％-92．5％）明显高于同组的TGA（44．2％）、TMA（69．8％），甲减组TPO-Ab的阳性值（平均57．4％）明显高于甲亢组（31．2％）和单纯甲状腺肿组（17．6％），差异有显著意义（P〈0．01）。结诊!TPO-Ab对自身角癌件甲状腺疾病的诊断、治疗和预后评估具右一定的临床价值．

Study on Serum Thyroid Peroxidase Antibody Levels in Autoimmune Thyroid Disease

Objective To investigate the clinical significance of changes of serum thyroid peroxidase antibody(TPO-Ab) in patients with hyperthyroidism,hypothyroidism and simple goiter.Methods Serum TPO-Ab,TMA,TGA and FT3,FT4,TSH levels were measured with radioimmunoassay(RIA) in 69 patients with hyperthyroidism,53 patients with hypothyroidism,45 patients with simple goiter and 20 controls.Results The positive rate of thyroid peroxidase antibody(TPO-Ab)(82%~92.5%) was higher than that of thyroidglobulim antibody(TGA)(44.2%) and thyroid microsome antibody(TMA)(60.4~69.8%) in all patients with AICD.Conclusion TPO-Ab could be taken as an important indicator in assessment of treatment and prognosis in patients with autoimmune thyroid diseases.