| 一叶萩碱全合成的研究 |
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| 引用本文： | 奚凤德,梁晓天. 一叶萩碱全合成的研究[J]. 药学学报, 1992, 27(5): 349-352 |
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| 作者姓名： | 奚凤德 梁晓天 |
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| 作者单位： | 中国医学科学院药物研究所,北京100050 |
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| 摘 要： | 以1,4-环己二酮为原料经与哌啶缩合、还原、乙酸汞环合、碱催化分子内缩合等11步反应完成了一叶萩碱的全合成。合成品的熔点及光谱数据与天然一叶萩碱的熔点及光谱数据一致。
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| 关 键 词： | 一叶萩碱 全合成 天然产物 |
| 收稿时间： | 1981-05-03 |
TOTAL SYNTHESIS OF SECURININE |
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| FD Xi,XT Liang. TOTAL SYNTHESIS OF SECURININE[J]. Acta pharmaceutica Sinica, 1992, 27(5): 349-352 |
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| Authors: | FD Xi XT Liang |
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| Affiliation: | Institute of Materia Medica, Chinese Academy of Medical Sciences, Beijing. |
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| Abstract: | Securinine, an alkaloid having strychnine-like action was synthesized using 1,4-cyclohexanedione as the starting material through the following sequence of reactions: condensation with piperidine, reduction, cyclization catalyzed by mercuric acetate and intramolecular condensation, totally in eleven steps. The IR, 1HNMR and melting point of the synthetic product is identical with those of natural securinine. |
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| Keywords: | Total synthesis Natural product Securinine |
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