| 蛇床子止痒有效组分筛选及作用机制研究 |
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| 引用本文： | 刘明平,吴依娜,韦品清,吴庆光,刘四军. 蛇床子止痒有效组分筛选及作用机制研究[J]. 中医药导报, 2009, 15(7): 66-67 |
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| 作者姓名： | 刘明平 吴依娜 韦品清 吴庆光 刘四军 |
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| 作者单位： | 广州中医药大学,广东,广州,510405;广州中医药大学,广东,广州,510405;广州中医药大学,广东,广州,510405;广州中医药大学,广东,广州,510405;广州中医药大学,广东,广州,510405 |
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| 摘 要： | 目的:筛选蛇床子止痒的有效组分,并探讨其作用机制.方法:采用磷酸组胺致豚鼠瘙痒及低分子右旋糖酐致小鼠瘙痒模型,分别观察蛇床子醇提物、水提物及挥发油的止痒作用;通过其对组胺致离体回肠收缩的影响,探讨其作用机制.结果:蛇床子醇提物及挥发油可显著提高磷酸组胺致豚鼠致瘁闲,减少低分子右旋糖酐致小鼠瘙痒次数,缩短瘙痒时间,而水提物止痒作用不明显.醇提物及挥发油均能抑制磷酸组胺致离体回肠的收缩幅度.结论:蛇床子止痒的有效组分为其醇提物及挥发油,其止痒机制与拮抗组胺的释放相关.
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| 关 键 词： | 蛇床子 止痒 作用机制 |
Pharmacodynamics Study on Antipruritic Effective Constituents of Fructus Cnidii and Its Mechanism |
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| LIU Ming-Ping,Wu Yi-Na,WEI Ping-Qing,Wu Qing-Gunng,LIU Si-jun. Pharmacodynamics Study on Antipruritic Effective Constituents of Fructus Cnidii and Its Mechanism[J]. GUIDING JOURNAL OF TCM, 2009, 15(7): 66-67 |
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| Authors: | LIU Ming-Ping Wu Yi-Na WEI Ping-Qing Wu Qing-Gunng LIU Si-jun |
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| Affiliation: | LIU Ming-Ping Wu Yi-Na WEI Ping-Qing Wu Qing-Gunag LIU Si-jun College of Chinese Medicine of Guang Zhou University of Chinese Medicine,Guang Dong,Guang Zhou,510405 |
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| Abstract: | Objective:To research the pharmacodynamics and its related mechanism on antipruritic constituents of fructus Cnidii.Methods:By obsering the effect of ethanol and water extracts,volatile constituents affect histamine acid phosphate or dextranum-40 inducing itching reaction on guinea pigs and mice and the affect histamine acid phosphate inducing shrinkage reaction of ileum in vitio.Results:ethanol extracts,volatile constituents of fructus Cnidii.can obviously improve histamine acid phosphate inducing itch on ... |
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| Keywords: | Fructus Cnidii Antipruritic Mechanism. |
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