清胃泻火养阴法治疗复发性口疮的临床及实验研究

目的 观察清胃泻火养阴法（口疮平冲剂）对复发性口疮（ＲＯＵ）的临床疗效，探讨其作用机理。方法 对用口疮平冲剂治疗的１４８例复发性口疮患者与用雷公藤多甙片治疗的４９例患者进行随机对照观察，评定其控制溃疡复发、延长发作间歇期、改善局部症状的效果及对体液、细胞免疫功能的影响。通过动物实验，观察口疮平冲剂调节免疫功能，抗渗出、消炎镇痛等方面的作用。结果 临床愈显率６２．８％，总有效率８９．９％，明显优于对

Clinical and Experimental Studies on Clearing Away Stomach Heat Purging Fire and Nourishing Yin Principle in Treating Patients of Recurrent Aphthae

Objective: To observe the therapeutic effect of Kouchuangping granule (KCP) on recurrent aphthae and explore its mechanism. Methods: One hundred and forty eight patients treated with KCP were observed and compared with 49 patients treated with tripterygii multiglycoside tablet as control in controlling relapse, prolonging intermittent period, improving local symptom and the influence on humoral and cellular immunity. In animal experiment, the effects of KCP on immunologic function, anti exudation, anti inflammation and analgesia were studied. Results: The clinical markedly effective and cure rate of the KCP group was 62.8% and the total effective rate was 89.9%, which were significantly higher than those of the control group (40.8% and 75.5%, P<0 01, P<0 05). In the KCP group, the intermittent period of aphthous ulcer recurrence was prolonged to 6 months and the local symptoms were markedly improved, the differences were significant as compared with those before treatment and those in the control group (P<0 01 or 0.05). The KCP showed effects in suppressing humoral immunity and enhancing cellular immunity. Results of experimental study showed that KCP could inhibit the supernormal reaction of cellular immunity to prevent and treat the hypersentivity caused erosion and ulceration of mucosae, inhibit capillary permeability and WBC migration and abate the 5 hydroxytryptamine (5 HT) and histamine induced local swelling and pain. Conclusion: KCP has a significant effect in treating recurrent aphthae, the mechanism might be related with its effect on immunoregulation, anti inflammation and anti exudation.