| sFlt-1mRNA在子痫前期患者胎盘中的表达 |
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| 引用本文： | 陈茜,陈汉平.sFlt-1mRNA在子痫前期患者胎盘中的表达[J].中国优生与遗传杂志,2008,16(5):54-55. |
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| 作者姓名： | 陈茜 陈汉平 |
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| 作者单位： | 华中科技大学同济医学院附属同济医院妇产科,武汉,430030 |
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| 摘 要： | 目的检测可溶性血管内皮生长因子受体-1（soluble fms-like tyrosine kinase-1,sFlt-1）在子痫前期胎盘组织中的mRNA表达水平,探讨其在子痫前期发生发展中的作用。方法用半定量逆转录聚合酶链反应（RT-PCR）技术检测25例子痫前期患者（轻度（n=8）,重度（n=17））和15例正常妊娠孕妇。结果（1）sFlt-1mRNA在正常孕妇、轻度和重子痫前期患者胎盘组织中均有表达。（2）sFlt-1mRNA的表达水平在轻度和重度子痫前期组均高于正常组,差别有显著性（P〈0.01）。结论胎盘组织中sFlt-1mRNA的过度表达可能与子痫前期的发病有关,并参与了子痫前期的病理生理过程。
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| 关 键 词： | 子痫前期 血管内皮生长因子 可溶性血管内皮生长因子受体-1 |
| 文章编号： | 1006-9534(2008)05-0054-02 |
| 修稿时间： | 2008年3月12日 |
Expression of soluble vascular endothelial growth factor receptor-1 mRNA in the placenta of preeclampsia |
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| CHEN Xi,CHEN Han-ping.Expression of soluble vascular endothelial growth factor receptor-1 mRNA in the placenta of preeclampsia[J].Chinese Journal of Birth Health & Heredity,2008,16(5):54-55. |
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| Authors: | CHEN Xi CHEN Han-ping |
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| Institution: | CHEN Xi;CHEN Han-ping.(Department of Obstetrics and Gynecology;Tongji Hospital;Tongji Medical College;Huazhong University of Science and Technology;Wuhan 430030) |
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| Abstract: | Objective：To detect the level of soluble vascular endothelial factor receptor-1 mRNA in the placenta of preeclampsia patients and their relation to the pathogenesis of preeclampsia.Methods：Expression of sFlt-1 mRNA in placenta from 25 cases of preeclampsia（8 mild preeclampsia,17 sever preeclampsia） and 15 cases of normal term pregnant（control group） was detected by semi-quantitative RT-PCR.Results：（1）Expressions of sFlt-1 mRNA in placentas were both detected in preeclampsia and normal group.（2）The levels of sFlt-1 mRNA in the mild and severe groups were higher than normal group.（P〈0.01） Conclusion：Abnormal expression of sFlt-1 in placenta might be related with preeclampsia and play a role in the pathophysiological process of preeclampsia. |
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| Keywords: | Preeclampsia Plancenta Soluble vascular endothelial growth factor rceptors-1 |
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